Nature Communications (Dec 2020)

Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation

  • Christophe J. Dubois,
  • Jessica Fawcett-Patel,
  • Paul A. Katzman,
  • Siqiong June Liu

DOI
https://doi.org/10.1038/s41467-020-20121-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Endocannabinoid levels are controlled by the fine balance between their synthesis and degradation. Here, the authors show that memory formation through fear conditioning selectively accelerates the degradation of endocannabinoids in the cerebellum via a lasting increase in GABA release.