The calcium channel subunit α2δ-3 organizes synapses via an activity-dependent and autocrine BMP signaling pathway

Abstract

Activity-dependent pathways are important for synapse function but the molecular links to synapse function are not clear. The authors show that the Ca2 + channel subunit α2δ-3 provides an extracellular scaffold for autocrine BMP signalling at the Drosophila neuromuscular junction.