923 Hedgehog signaling drives epithelial-to-mesenchymal transition, immune evasion, and anti-PD-1 resistance through coordinated upregulation of Wnt ligands and PGE2 synthesis

• Brent Hanks,
• Nicholas DeVito,
• Michael Plebanek,
• Balamayooran Theivanthiran,
• Michael Sturdivant,
• Y-Van Nguyen

Affiliations

Brent Hanks

Aff630 grid.26009.3d0000000419367961Duke Cancer Institute Durham NC USA

Nicholas DeVito

Oxford University, Oxford, UK

Michael Plebanek

Duke University, Durham, NC, United States

Balamayooran Theivanthiran

Duke University, Durham, NC, United States

Michael Sturdivant

2University of North Carolina, Chapel HIll, NC, USA

Y-Van Nguyen

1Duke University Medical Center, Durham, NC, USA