MRI in Chemotherapy induced Leukoencephalopathy: Report of Two Cases and Radiologist’s Perspective

Abstract

Leukoencephalopathy is a progressive white matter disease primarily caused due to myelin damage by a variety of factors. Chemotherapy for oncological treatment is an uncommon but important cause of potentially reversible leukoencephalopathy. In current radiological setting, conventional and diffusion weighted MRI play a significant role in early and accurate detection of this entity. We are hereby presenting MRI evaluation of two cases of methotrexate and 5-fluorouracil induced toxic leukoencephalopathy.

Keywords

• diffusion weighted imaging
• methotrexate
• neurotoxicity
• toxic encephalopathy