Effects of cadmium and high-fat diet on essential metal concentration in the mouse testis

Bin Zhou; Adrienne Gentry; Qian Xu; Jamie L. Young; Xiaofang Yan; Kelly Pagidas; Yu Yang; Walter H. Watson; Maiying Kong; Lu Cai; Jonathan H. Freedman

Toxicology Reports (Jan 2021)

Effects of cadmium and high-fat diet on essential metal concentration in the mouse testis

Bin Zhou,
Adrienne Gentry,
Qian Xu,
Jamie L. Young,
Xiaofang Yan,
Kelly Pagidas,
Yu Yang,
Walter H. Watson,
Maiying Kong,
Lu Cai,
Jonathan H. Freedman

Affiliations

Bin Zhou: Pediatric Research Institute, Department of Pediatrics, University of Louisville School of Medicine, USA; The Affiliated Children’s Hospital of Nanchang University, Department of Endocrinology, Metabolism, and Genetics, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China
Adrienne Gentry: Department of Obstetrics & Gynecology and Women’s Health, University of Louisville School of Medicine, USA
Qian Xu: Department of Bioinformatics and Biostatistics, School of Public Health and Information Sciences, University of Louisville, USA
Jamie L. Young: Pediatric Research Institute, Department of Pediatrics, University of Louisville School of Medicine, USA; Department of Pharmacology and Toxicology, University of LouisvilleSchool of Medicine, University of Louisville, USA
Xiaofang Yan: Department of Bioinformatics and Biostatistics, School of Public Health and Information Sciences, University of Louisville, USA
Kelly Pagidas: Department of Obstetrics & Gynecology and Women’s Health, University of Louisville School of Medicine, USA
Yu Yang: The Affiliated Children’s Hospital of Nanchang University, Department of Endocrinology, Metabolism, and Genetics, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China
Walter H. Watson: Department of Pharmacology and Toxicology, University of LouisvilleSchool of Medicine, University of Louisville, USA; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA
Maiying Kong: Department of Bioinformatics and Biostatistics, School of Public Health and Information Sciences, University of Louisville, USA
Lu Cai: Pediatric Research Institute, Department of Pediatrics, University of Louisville School of Medicine, USA; Department of Pharmacology and Toxicology, University of LouisvilleSchool of Medicine, University of Louisville, USA; Corresponding author at: Pediatric Research Institute, 570 S. Preston Street, Rm: 304 F, Louisville, KY, 40202, USA.
Jonathan H. Freedman: Department of Pharmacology and Toxicology, University of LouisvilleSchool of Medicine, University of Louisville, USA; Corresponding author at: Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.

Journal volume & issue: Vol. 8
pp. 718 – 723

Abstract

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The effects of exposure to the environmental toxicant cadmium, in combination with obesity, on the metal content in mouse testis were evaluated. Starting in utero and continuing through to 10 or 24 weeks post-weaning, male mice were exposed to cadmium (0, 0.5 or 5 ppm), and fed either a low (LFD) or high fat diet (HFD) post-weaning. Testicular levels of cadmium and essential metals were determined 10 and 24 weeks post-weaning by ICP-MS. Similar to what has been previously observed in the liver, kidney, heart and brain, significant levels of cadmium accumulated in the testis under all exposure conditions. Additionally, HFD-fed animals accumulated more cadmium than did their LFD-treated counterparts. Both treatments affected essential metal homeostasis in the testis. These findings suggest that cadmium and obesity may compromise the reproductive potential in the male mouse by disrupting essential metal levels.

Published in Toxicology Reports

ISSN: 2214-7500 (Online)
Publisher: Elsevier
Country of publisher: Ireland
LCC subjects: Medicine: Public aspects of medicine: Toxicology. Poisons
Website: http://www.journals.elsevier.com/toxicology-reports/

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