SHORT-TERM EFFECTS OF DIETARY PROTEIN RESTRICTION ON THE PROGRESSION OF CHRONIC KIDNEY DISEASE IN PATIENTS UNDERGOING CONSERVATIVE TREATMENT

Abstract

In chronic kidney disease (CKD) patients undergoing conservative low-protein diets ameliorate uremic symptoms and certain CKD complications and, can slow progression of renal disease. The aim of this study was to determine the short-term effects of protein restriction on the progression of CKD. Twenty-six CKD patients from the Renal Nutrition Ambulatory, Nutrition Faculty, UFF, Niterói, Brazil (63.1±13.7 years, 13 men, and % body fat for men, 25.0±6.9% and for women, 36.0±3.3%) were analysed. All patients were originally prescribed low-protein diets and energy according to NKF-K/DOQI recommendations. One month later, their body mass index, creatinine, urea and creatinine clearance (calculated by Cockcroft-Gault) were evaluated (Table). The patients reported good adherence diet in clinical records. In spite of the short period of time, the dietary protein restriction during conservative treatment seems slowing the progression of kidney disease. Parameters Before (n=26) After (n=26) BMI (kg/m2) 28.6±6.8 28.0±6.9* Creatinine (mg/dL) 2.1±0.8 2.0±0.9 CrCl (mL/min) 35.8±15.7 40.9±20.0* Urea (mg/dL) 85.5±29.4 77.4±32.3 ⁎ p<0,005