Stress gates an astrocytic energy reservoir to impair synaptic plasticity

Ciaran Murphy-Royal; April D. Johnston; Andrew K. J. Boyce; Blanca Diaz-Castro; Adam Institoris; Govind Peringod; Oliver Zhang; Randy F. Stout; David C. Spray; Roger J. Thompson; Baljit S. Khakh; Jaideep S. Bains; Grant R. Gordon

doi:10.1038/s41467-020-15778-9

Nature Communications (Apr 2020)

Stress gates an astrocytic energy reservoir to impair synaptic plasticity

Ciaran Murphy-Royal,
April D. Johnston,
Andrew K. J. Boyce,
Blanca Diaz-Castro,
Adam Institoris,
Govind Peringod,
Oliver Zhang,
Randy F. Stout,
David C. Spray,
Roger J. Thompson,
Baljit S. Khakh,
Jaideep S. Bains,
Grant R. Gordon

Affiliations

Ciaran Murphy-Royal: Hotchkiss Brain Institute, Cumming School of Medicine, Department of Physiology and Pharmacology, University of Calgary
April D. Johnston: Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, UCLA
Andrew K. J. Boyce: Hotchkiss Brain Institute, Cumming School of Medicine, Department of Physiology and Pharmacology, University of Calgary
Blanca Diaz-Castro: Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, UCLA
Adam Institoris: Hotchkiss Brain Institute, Cumming School of Medicine, Department of Physiology and Pharmacology, University of Calgary
Govind Peringod: Hotchkiss Brain Institute, Cumming School of Medicine, Department of Physiology and Pharmacology, University of Calgary
Oliver Zhang: Hotchkiss Brain Institute, Cumming School of Medicine, Department of Physiology and Pharmacology, University of Calgary
Randy F. Stout: Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine
David C. Spray: Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine
Roger J. Thompson: Hotchkiss Brain Institute, Cumming School of Medicine, Department of Physiology and Pharmacology, University of Calgary
Baljit S. Khakh: Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, UCLA
Jaideep S. Bains: Hotchkiss Brain Institute, Cumming School of Medicine, Department of Physiology and Pharmacology, University of Calgary
Grant R. Gordon: Hotchkiss Brain Institute, Cumming School of Medicine, Department of Physiology and Pharmacology, University of Calgary

DOI: https://doi.org/10.1038/s41467-020-15778-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 18

Abstract

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Enduring changes in synaptic efficacy are highly sensitive to stress. Here, the authors show that astrocytic delivery of metabolites has an important role in the stress-mediated impairment of synaptic plasticity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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