HIV-1 Vpr Induces Widespread Transcriptomic Changes in CD4
<sup>+</sup>
T Cells Early Postinfection

Hélène Bauby; Christopher C. Ward; Rupert Hugh-White; Chad M. Swanson; Reiner Schulz; Caroline Goujon; Michael H. Malim

doi:10.1128/mBio.01369-21

mBio (Jun 2021)

HIV-1 Vpr Induces Widespread Transcriptomic Changes in CD4 <sup>+</sup> T Cells Early Postinfection

Hélène Bauby,
Christopher C. Ward,
Rupert Hugh-White,
Chad M. Swanson,
Reiner Schulz,
Caroline Goujon,
Michael H. Malim

Affiliations

Hélène Bauby: Department of Infectious Diseases, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
Christopher C. Ward: ORCiD; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
Rupert Hugh-White: Department of Infectious Diseases, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
Chad M. Swanson: ORCiD; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
Reiner Schulz: Department of Infectious Diseases, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
Caroline Goujon: ORCiD; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
Michael H. Malim: Department of Infectious Diseases, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom

DOI: https://doi.org/10.1128/mBio.01369-21
Journal volume & issue: Vol. 12, no. 3

Abstract

Read online

HIV-1, while now treatable, remains an important human pathogen causing significant morbidity and mortality globally. The virus predominantly infects CD4 +

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal