Nature Communications (May 2017)
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
- Cecilie Morland,
- Krister A. Andersson,
- Øyvind P. Haugen,
- Alena Hadzic,
- Liv Kleppa,
- Andreas Gille,
- Johanne E. Rinholm,
- Vuk Palibrk,
- Elisabeth H. Diget,
- Lauritz H. Kennedy,
- Tomas Stølen,
- Eivind Hennestad,
- Olve Moldestad,
- Yiqing Cai,
- Maja Puchades,
- Stefan Offermanns,
- Koen Vervaeke,
- Magnar Bjørås,
- Ulrik Wisløff,
- Jon Storm-Mathisen,
- Linda H. Bergersen
Affiliations
- Cecilie Morland
- Department of Oral Biology, The Brain and Muscle Energy Group, Electron Microscopy Laboratory, University of Oslo
- Krister A. Andersson
- Department of Oral Biology, The Brain and Muscle Energy Group, Electron Microscopy Laboratory, University of Oslo
- Øyvind P. Haugen
- Department of Oral Biology, The Brain and Muscle Energy Group, Electron Microscopy Laboratory, University of Oslo
- Alena Hadzic
- Department of Oral Biology, The Brain and Muscle Energy Group, Electron Microscopy Laboratory, University of Oslo
- Liv Kleppa
- Department of Oral Biology, The Brain and Muscle Energy Group, Electron Microscopy Laboratory, University of Oslo
- Andreas Gille
- Institute for Experimental and Clinical Pharmacology and Toxicology, Mannheim Medical Faculty, Heidelberg University
- Johanne E. Rinholm
- Department of Oral Biology, The Brain and Muscle Energy Group, Electron Microscopy Laboratory, University of Oslo
- Vuk Palibrk
- Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology
- Elisabeth H. Diget
- Department of Oral Biology, The Brain and Muscle Energy Group, Electron Microscopy Laboratory, University of Oslo
- Lauritz H. Kennedy
- Department of Oral Biology, The Brain and Muscle Energy Group, Electron Microscopy Laboratory, University of Oslo
- Tomas Stølen
- Department of Circulation and Medical Imaging, K.G. Jebsen Center of Exercise in Medicine, Norwegian University of Science and Technology
- Eivind Hennestad
- Department of Physiology, Laboratory of Neural Computation, University of Oslo
- Olve Moldestad
- Centre for Rare Disorders, Oslo University Hospital, Rikshospitalet
- Yiqing Cai
- Department of Oral Biology, The Brain and Muscle Energy Group, Electron Microscopy Laboratory, University of Oslo
- Maja Puchades
- Division of Anatomy, Department of Molecular Medicine, The Synaptic Neurochemistry Lab, Institute of Basic Medical Sciences, Healthy Brain Ageing Centre, University of Oslo
- Stefan Offermanns
- Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research
- Koen Vervaeke
- Department of Physiology, Laboratory of Neural Computation, University of Oslo
- Magnar Bjørås
- Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology
- Ulrik Wisløff
- Department of Circulation and Medical Imaging, K.G. Jebsen Center of Exercise in Medicine, Norwegian University of Science and Technology
- Jon Storm-Mathisen
- Division of Anatomy, Department of Molecular Medicine, The Synaptic Neurochemistry Lab, Institute of Basic Medical Sciences, Healthy Brain Ageing Centre, University of Oslo
- Linda H. Bergersen
- Department of Oral Biology, The Brain and Muscle Energy Group, Electron Microscopy Laboratory, University of Oslo
- DOI
- https://doi.org/10.1038/ncomms15557
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 9
Abstract
Physical exercise promotes brain angiogenesis through an unknown signalling cascade. Morlandet al. identify the elusive muscle-brain communication and show that lactate produced by muscle activity binds to its receptor HCAR1 in brain vessel-surrounding cells, stimulating VEGF production and brain angiogenesis.
