A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

Adele M. Alchahin; Shenglin Mei; Ioanna Tsea; Taghreed Hirz; Youmna Kfoury; Douglas Dahl; Chin-Lee Wu; Alexander O. Subtelny; Shulin Wu; David T. Scadden; John H. Shin; Philip J. Saylor; David B. Sykes; Peter V. Kharchenko; Ninib Baryawno

doi:10.1038/s41467-022-33375-w

Nature Communications (Sep 2022)

A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

Adele M. Alchahin,
Shenglin Mei,
Ioanna Tsea,
Taghreed Hirz,
Youmna Kfoury,
Douglas Dahl,
Chin-Lee Wu,
Alexander O. Subtelny,
Shulin Wu,
David T. Scadden,
John H. Shin,
Philip J. Saylor,
David B. Sykes,
Peter V. Kharchenko,
Ninib Baryawno

Affiliations

Adele M. Alchahin: Childhood Cancer Research unit, Department of Children’s and Women’s Health, Karolinska Institutet, Karolinska University Hospital
Shenglin Mei: Department of Biomedical Informatics, Harvard Medical School
Ioanna Tsea: Childhood Cancer Research unit, Department of Children’s and Women’s Health, Karolinska Institutet, Karolinska University Hospital
Taghreed Hirz: Center for Regenerative Medicine, Massachusetts General Hospital
Youmna Kfoury: Center for Regenerative Medicine, Massachusetts General Hospital
Douglas Dahl: Department of Urology, Massachusetts General Hospital, Harvard Medical School
Chin-Lee Wu: Department of Pathology, Massachusetts General Hospital, Harvard Medical School
Alexander O. Subtelny: Department of Pathology, Massachusetts General Hospital, Harvard Medical School
Shulin Wu: Department of Pathology, Massachusetts General Hospital, Harvard Medical School
David T. Scadden: Center for Regenerative Medicine, Massachusetts General Hospital
John H. Shin: Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School
Philip J. Saylor: Massachusetts General Hospital Cancer Center, Harvard Medical School
David B. Sykes: Center for Regenerative Medicine, Massachusetts General Hospital
Peter V. Kharchenko: Department of Biomedical Informatics, Harvard Medical School
Ninib Baryawno: Childhood Cancer Research unit, Department of Children’s and Women’s Health, Karolinska Institutet, Karolinska University Hospital

DOI: https://doi.org/10.1038/s41467-022-33375-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Metastatic clear cell renal cell carcinoma has a poor prognosis. Here, the authors use single cell RNA-seq to show a distinct gene expression signature in the primary tumour of metastatic patients, and highlights immune cell receptor interactions as potential therapeutic targets.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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