Nature Communications (Jun 2021)

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

  • Delin Chen,
  • Bo Chu,
  • Xin Yang,
  • Zhaoqi Liu,
  • Ying Jin,
  • Ning Kon,
  • Raul Rabadan,
  • Xuejun Jiang,
  • Brent R. Stockwell,
  • Wei Gu

DOI
https://doi.org/10.1038/s41467-021-23902-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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p53 is able to induce ferroptosis in response to reactive oxygen species (ROS)-induced stress and suppresses tumour growth. Here, the authors show that iPLA2β suppresses p53-medated ferroptosis by cleaving and detoxifying peroxidized lipids and that this is independent of canonical ferroptosis regulator GPX4.