Nature Communications (May 2022)
Elucidating Human Milk Oligosaccharide biosynthetic genes through network-based multi-omics integration
- Benjamin P. Kellman,
- Anne Richelle,
- Jeong-Yeh Yang,
- Digantkumar Chapla,
- Austin W. T. Chiang,
- Julia A. Najera,
- Chenguang Liang,
- Annalee Fürst,
- Bokan Bao,
- Natalia Koga,
- Mahmoud A. Mohammad,
- Anders Bech Bruntse,
- Morey W. Haymond,
- Kelley W. Moremen,
- Lars Bode,
- Nathan E. Lewis
Affiliations
- Benjamin P. Kellman
- Department of Pediatrics, University of California, San Diego
- Anne Richelle
- Department of Pediatrics, University of California, San Diego
- Jeong-Yeh Yang
- Complex Carbohydrate Research Center, University of Georgia
- Digantkumar Chapla
- Complex Carbohydrate Research Center, University of Georgia
- Austin W. T. Chiang
- Department of Pediatrics, University of California, San Diego
- Julia A. Najera
- Department of Pediatrics, University of California, San Diego
- Chenguang Liang
- Department of Pediatrics, University of California, San Diego
- Annalee Fürst
- Department of Pediatrics, University of California, San Diego
- Bokan Bao
- Department of Pediatrics, University of California, San Diego
- Natalia Koga
- Department of Pediatrics, University of California, San Diego
- Mahmoud A. Mohammad
- Department of Pediatrics, Children’s Nutrition Research Center, US Department of Agriculture/Agricultural Research Service, Baylor College of Medicine
- Anders Bech Bruntse
- Department of Pediatrics, University of California, San Diego
- Morey W. Haymond
- Department of Pediatrics, Children’s Nutrition Research Center, US Department of Agriculture/Agricultural Research Service, Baylor College of Medicine
- Kelley W. Moremen
- Complex Carbohydrate Research Center, University of Georgia
- Lars Bode
- Department of Pediatrics, University of California, San Diego
- Nathan E. Lewis
- Department of Pediatrics, University of California, San Diego
- DOI
- https://doi.org/10.1038/s41467-022-29867-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Human milk oligosaccharides are fundamental to infant health. Here the authors deploy a multi-omics systems biology approach to elucidate their biosynthetic network, including the associated enzymes and likely structures of ambiguous oligosaccharides.
