Japanese encephalitis virus neuropenetrance is driven by mast cell chymase

Justin T. Hsieh; Abhay P. S. Rathore; Gayathri Soundarajan; Ashley L. St. John

doi:10.1038/s41467-019-08641-z

Nature Communications (Feb 2019)

Japanese encephalitis virus neuropenetrance is driven by mast cell chymase

Justin T. Hsieh,
Abhay P. S. Rathore,
Gayathri Soundarajan,
Ashley L. St. John

Affiliations

Justin T. Hsieh: Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Abhay P. S. Rathore: Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Gayathri Soundarajan: Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Ashley L. St. John: Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School

DOI: https://doi.org/10.1038/s41467-019-08641-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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How Japanese encephalitis virus (JEV) penetrates the blood-brain barrier (BBB) remains unclear. Here, using a genetic mouse model and a virulent JEV strain, the authors show that perivascular mast cells (MC) mediate JEV neuroinvasion and identify the MC-protease chymase as a potential therapeutic target.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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