Nature Communications (Feb 2017)

PEGylated graphene oxide elicits strong immunological responses despite surface passivation

  • Nana Luo,
  • Jeffrey K. Weber,
  • Shuang Wang,
  • Binquan Luan,
  • Hua Yue,
  • Xiaobo Xi,
  • Jing Du,
  • Zaixing Yang,
  • Wei Wei,
  • Ruhong Zhou,
  • Guanghui Ma

DOI
https://doi.org/10.1038/ncomms14537
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Polyethylene glycol has been widely utilized to functionalize nanomaterials in order to improve their biocompatibility. Here, the authors demonstrate that PEGylated nano-graphene oxide can elicit an inflammatory response, contradicting current literature.