BMC Infectious Diseases (Aug 2012)

<it>Campylobacter</it> antimicrobial resistance in Peru: a ten-year observational study

  • Pollett Simon,
  • Rocha Claudio,
  • Zerpa Rito,
  • Patiño Lilian,
  • Valencia Augusto,
  • Camiña Máximo,
  • Guevara José,
  • Lopez Martha,
  • Chuquiray Nancy,
  • Salazar-Lindo Eduardo,
  • Calampa Carlos,
  • Casapia Martín,
  • Meza Rina,
  • Bernal Maruja,
  • Tilley Drake,
  • Gregory Michael,
  • Maves Ryan,
  • Hall Eric,
  • Jones Franca,
  • Arriola C,
  • Rosenbaum Marieke,
  • Perez Juan,
  • Kasper Matthew

DOI
https://doi.org/10.1186/1471-2334-12-193
Journal volume & issue
Vol. 12, no. 1
p. 193

Abstract

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Abstract Background Campylobacter jejuni and Campylobacter coli are food-borne pathogens of great importance and feature prominently in the etiology of developing world enteritis and travellers’ diarrhoea. Increasing antimicrobial resistant Campylobacter prevalence has been described globally, yet data from Peru is limited. Our objective was to describe the prevalence trends of fluoroquinolone and macrolide-resistant C. jejuni and C. coli stool isolates from three regions in Peru over a ten-year period. Methods Surveillance for enteric pathogens was conducted in Lima, Iquitos and Cusco between 2001 and 2010. Campylobacter stool isolates were tested for susceptibilities to ciprofloxacin, azithromycin and erythromycin. Susceptibilities were reviewed for 4652 isolates from Lima ( n = 3419), Iquitos ( n = 625) and Cusco ( n = 608). Results Comparing the study periods of 2001-2005 and 2006-2010, prevalence of ciprofloxacin-resistant C. jejuni isolates rose in the study areas of Lima (73.1% to 89.8%, p p C. coli rates also increased in Lima (48.1% to 87.4%, p p = 0.005). Small but significant increases in azithromycin-resistant and erythromycin-resistant C. jejuni prevalence were noted in Iquitos (2.2% to 14.9%, p p = 0.002), and erythromycin-resistant C. coli rates increased in Lima (0.0% to 5.3%, p = 0.038). The prevalence of C. jejuni isolates resistant to both ciprofloxacin and azithromycin increased in Iquitos (0.3% to 14.9%, p C. jejuni isolates resistant to both ciprofloxacin and erythromycin rose in Iquitos (0.0% to 14.9%, p C. coli prevalence increased in Lima (0.0% to 5.3%, p = 0.034). Conclusions These results have implications for the empirical management of enterocolitis in Peru. Ongoing surveillance is essential to guide appropriate antimicrobial use in this setting. Local epidemiological studies to explore the relationship between increasing antimicrobial resistance and agricultural or human antibiotic use may be valuable.

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