Proceedings
(Aug 2017)
Detection of Adrenaline Based on Bioelectrocatalytical System to Support Tumor Diagnostic Technology
Denise Molinnus,
Gabriel Hardt,
Larissa Käver,
Holger S. Willenberg,
Arshak Poghossian,
Michael Keusgen,
Michael J. Schöning
Affiliations
Denise Molinnus
Institute of Nano- and Biotechnologies (INB), FH Aachen, Campus Jülich, Heinrich-Mußmann-Street 1, 52428 Jülich, Germany
Gabriel Hardt
Institute of Nano- and Biotechnologies (INB), FH Aachen, Campus Jülich, Heinrich-Mußmann-Street 1, 52428 Jülich, Germany
Larissa Käver
Institute of Nano- and Biotechnologies (INB), FH Aachen, Campus Jülich, Heinrich-Mußmann-Street 1, 52428 Jülich, Germany
Holger S. Willenberg
Division of Endocrinology and Metabolism, Rostock University Medical Center, Ernst-Heydemann-Street 6, 18057 Rostock, Germany
Arshak Poghossian
Institute of Nano- and Biotechnologies (INB), FH Aachen, Campus Jülich, Heinrich-Mußmann-Street 1, 52428 Jülich, Germany
Michael Keusgen
Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6-10, 35037 Marburg, Germany
Michael J. Schöning
Institute of Nano- and Biotechnologies (INB), FH Aachen, Campus Jülich, Heinrich-Mußmann-Street 1, 52428 Jülich, Germany
DOI
https://doi.org/10.3390/proceedings1040506
Journal volume & issue
Vol. 1,
no. 4
Abstract
Read online
An amperometric biosensor based on the bioelectrocatalytic measurement principle for the detection of adrenaline has been developed. The adrenaline sensor has been prepared by modification of a platinum thin-film electrode with a pyrroloquinoline quinone-dependent glucose dehydrogenase. The enzyme was immobilized via cross-linking method. Lower detection limit of 1 nM of adrenaline has been achieved by measuring at physiological level at pH 7.4.
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