Applying scientific methodologies to extract science and technology policies in development path is essential. Due to the multi-dimensions of cultural, political, economic, social and technological development, policy formulation in the context of holistic and systemic approach is needed. In this paper, we try to integrate two separate theories: a systematic problem-solving approach (including the Theory of Constraints Thinking Process) and the other in decision making and strategy formulation (QFD), to open new window in using theories underpinning in production and manufacturing environment (hard area) toward politics and social environments (soft area). Also the practical solutions to eliminate the bottlenecks of Iran’s NIS (as the case study), using experts’ idea in this field, are provided.