Nature Communications (Jul 2021)
Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection
- Sara De Biasi,
- Domenico Lo Tartaro,
- Lara Gibellini,
- Annamaria Paolini,
- Andrew Quong,
- Carlene Petes,
- Geneve Awong,
- Samuel Douglas,
- Dongxia Lin,
- Jordan Nieto,
- Francesco Maria Galassi,
- Rebecca Borella,
- Lucia Fidanza,
- Marco Mattioli,
- Chiara Leone,
- Isabella Neri,
- Marianna Meschiari,
- Luca Cicchetti,
- Anna Iannone,
- Tommaso Trenti,
- Mario Sarti,
- Massimo Girardis,
- Giovanni Guaraldi,
- Cristina Mussini,
- Fabio Facchinetti,
- Andrea Cossarizza
Affiliations
- Sara De Biasi
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Domenico Lo Tartaro
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Lara Gibellini
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Annamaria Paolini
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Andrew Quong
- Fluidigm Corporation
- Carlene Petes
- Fluidigm Corporation
- Geneve Awong
- Fluidigm Corporation
- Samuel Douglas
- Fluidigm Corporation
- Dongxia Lin
- Fluidigm Corporation
- Jordan Nieto
- Fluidigm Corporation
- Francesco Maria Galassi
- College of Humanities, Arts and Social Sciences, Flinders University
- Rebecca Borella
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Lucia Fidanza
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Marco Mattioli
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Chiara Leone
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Isabella Neri
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Marianna Meschiari
- Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia
- Luca Cicchetti
- Labospace
- Anna Iannone
- Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia School of Medicine
- Tommaso Trenti
- Department of Clinical Pathology, AOU Policlinico
- Mario Sarti
- Department of Clinical Pathology, AOU Policlinico
- Massimo Girardis
- Department of Anesthesia and Intensive Care, AOU Policlinico and University of Modena and Reggio Emilia
- Giovanni Guaraldi
- Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia
- Cristina Mussini
- Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia
- Fabio Facchinetti
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Andrea Cossarizza
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-24940-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
SARS-CoV-2 infection of expecting mothers has been reported. Here the authors profile the peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection to find grossly normal immune cell composition but heterogenous induction of pro-inflammatory cytokines, thereby implicating possible therapeutic targets for virus-induced damages during pregnancy.
