Nature Communications (Sep 2019)
Central nicotine induces browning through hypothalamic κ opioid receptor
- Patricia Seoane-Collazo,
- Laura Liñares-Pose,
- Eva Rial-Pensado,
- Amparo Romero-Picó,
- José María Moreno-Navarrete,
- Noelia Martínez-Sánchez,
- Pablo Garrido-Gil,
- Ramón Iglesias-Rey,
- Donald A. Morgan,
- Naoki Tomasini,
- Samuel Andrew Malone,
- Ana Senra,
- Cintia Folgueira,
- Gema Medina-Gomez,
- Tomás Sobrino,
- José L. Labandeira-García,
- Rubén Nogueiras,
- Ana I. Domingos,
- José-Manuel Fernández-Real,
- Kamal Rahmouni,
- Carlos Diéguez,
- Miguel López
Affiliations
- Patricia Seoane-Collazo
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Laura Liñares-Pose
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Eva Rial-Pensado
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Amparo Romero-Picó
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- José María Moreno-Navarrete
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)
- Noelia Martínez-Sánchez
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Pablo Garrido-Gil
- Department of Morphological Sciences, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Ramón Iglesias-Rey
- Clinical Neurosciences Research Laboratory, Instituto de Investigación Sanitaria
- Donald A. Morgan
- Department of Pharmacology, University of Iowa
- Naoki Tomasini
- Obesity Laboratory, Instituto Gulbenkian de Ciência
- Samuel Andrew Malone
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Ana Senra
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Cintia Folgueira
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Gema Medina-Gomez
- Department of Basic Sciences of Health, Area of Biochemistry and Molecular Biology, Universidad Rey Juan Carlos
- Tomás Sobrino
- Clinical Neurosciences Research Laboratory, Instituto de Investigación Sanitaria
- José L. Labandeira-García
- Department of Morphological Sciences, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Rubén Nogueiras
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Ana I. Domingos
- Department of Physiology, Anatomy and Genetics, University of Oxford
- José-Manuel Fernández-Real
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)
- Kamal Rahmouni
- Department of Pharmacology, University of Iowa
- Carlos Diéguez
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Miguel López
- Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- DOI
- https://doi.org/10.1038/s41467-019-12004-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Nicotine reduces food intake and increases energy expenditure in brown adipose tissue. Here the authors show that nicotine also induces white adipose tissue browning via central kappa opioid receptor action.
