Diagnostic Pathology (Nov 2022)
GATA3 expression in clear cell adenocarcinoma of the lower urinary tract: a potential diagnostic pitfall
- Mahmut Akgul,
- Robert Humble,
- Abdullah Osme,
- Servet Yuce,
- Elif N. Kocak,
- Parisa Najafzadeh,
- Ankur Sangoi,
- Niharika Pattnaik,
- Sourav Mishra,
- Shivani Sharma,
- Nada Shaker,
- Seema Kaushal,
- Manas Baisakh,
- Andrea R. Lightle,
- Bonnie L. Balzer,
- Guang-Qian Xiao,
- Gregory T. MacLennan,
- Adeboye O. Osunkoya,
- Anil Parwani,
- Liang Cheng,
- Andrew Bellizzi,
- Sambit K. Mohanty
Affiliations
- Mahmut Akgul
- Department of Pathology and Laboratory Medicine, Albany Medical Center
- Robert Humble
- Department of Pathology and Laboratory Medicine, University of Iowa
- Abdullah Osme
- Department of Pathology and Laboratory Medicine, University Hospitals Cleveland Medical Center
- Servet Yuce
- Department of Public Health, Istanbul University School of Medicine
- Elif N. Kocak
- Department of Public Health, Istanbul University School of Medicine
- Parisa Najafzadeh
- Department of Pathology, Keck School of Medicine, University of Southern California
- Ankur Sangoi
- Department of Pathology, El Camino Hospital
- Niharika Pattnaik
- SRL Diagnostics
- Sourav Mishra
- Apollo Hospitals
- Shivani Sharma
- DCP, Core Diagnostics
- Nada Shaker
- Department of Pathology and Laboratory Medicine, The Ohio State University Wexner Medical Center
- Seema Kaushal
- AIIMS
- Manas Baisakh
- Apollo Hospitals
- Andrea R. Lightle
- Department of Pathology and Laboratory Medicine, Albany Medical Center
- Bonnie L. Balzer
- Department of Pathology, Cedars-Sinai Hospital
- Guang-Qian Xiao
- Department of Pathology, Keck School of Medicine, University of Southern California
- Gregory T. MacLennan
- Department of Pathology and Laboratory Medicine, University Hospitals Cleveland Medical Center
- Adeboye O. Osunkoya
- Department of Pathology and Laboratory Medicine, Emory University
- Anil Parwani
- Department of Pathology and Laboratory Medicine, The Ohio State University Wexner Medical Center
- Liang Cheng
- Department of Pathology and Urology, Indiana University
- Andrew Bellizzi
- Department of Pathology and Laboratory Medicine, University of Iowa
- Sambit K. Mohanty
- DCP, Core Diagnostics
- DOI
- https://doi.org/10.1186/s13000-022-01269-6
- Journal volume & issue
-
Vol. 17,
no. 1
pp. 1 – 9
Abstract
Highlights Clear cell adenocarcinoma of the lower urinary tract is rare, with heterogenous morphology. GATA3 expression can be seen in these tumors, causing diagnostic challenge in the urinary tract or in the metastatic setting. Along with morphologic clues, immunohistochemical panel of PAX8, GATA3, and p63 might be useful to distinguish these tumors from urothelial carcinoma.
Keywords
