Nature Communications (Jul 2020)

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

  • Jack A. Bibby,
  • Harriet A. Purvis,
  • Thomas Hayday,
  • Anita Chandra,
  • Klaus Okkenhaug,
  • Sofia Rosenzweig,
  • Ivona Aksentijevich,
  • Michael Wood,
  • Helen J. Lachmann,
  • Claudia Kemper,
  • Andrew P. Cope,
  • Esperanza Perucha

DOI
https://doi.org/10.1038/s41467-020-17179-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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IL-10 production by B cells is integral to regulation and resolution of inflammation. Here the authors show that cholesterol metabolism can control B cell IL-10 production via a geranylgeranyl pyrophosphate-dependent mechanism.