Cancer Medicine (Sep 2023)

Demographics and access to head and neck cancer care in rural areas compared to urban areas in Germany

  • Julius M. Vahl,
  • Gabriele Nagel,
  • Ayla Grages,
  • Matthias Brand,
  • Adrian vonWitzleben,
  • Michael Sonntag,
  • Marie‐Nicole Theodoraki,
  • Jens Greve,
  • Tsima Aboukors,
  • Michael Denkinger,
  • Dhayana Dallmeier,
  • Christian Idel,
  • Thomas K. Hoffmann,
  • Simon Laban

DOI
https://doi.org/10.1002/cam4.6505
Journal volume & issue
Vol. 12, no. 18
pp. 18826 – 18836

Abstract

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Abstract Background Demographic development in rural and urban areas differs substantially. Demographics and access to specialized head and neck cancer centers may affect head and neck cancer patients' (HNCP) outcomes. Here, we compare epidemiological indicators and outcomes of HNCP in rural and urban Germany. Patients and Methods In a retrospective analysis of data from the Center for Cancer Registry Data (ZfKD) between 2002 and 2017, 212,920 HNCP were included. Incidence, demographics, travel distance to specialized centers, and ground values were compared between rural and urban areas with a focus on their association with patient outcomes. Results The mean age of HNCP was significantly higher in urban areas (mean difference = 1.4 years; p < 0.0001), but increased at a comparable rate (p = 0.26) in rural and urban areas during the observation period. Gender imbalance was higher in rural areas (mean ratio of men/women: 4.1 vs. 3.1; p < 0.0001), but showed a comparable trend toward equilibration in both, rural and urban districts (p = 0.46). The portion of HNCP of the entire HNCP population living in urban areas increased from 55.9% in the year 2002 to 76.4% in the year 2017. There was no significant difference or change in the ratio of advanced to low UICC stage during the observation period (p = 0.26). However, travel distances to medical centers were higher in rural areas, especially (p < 0.0001) in East Germany. Median survival of HNCP in rural areas was significantly lower than in urban areas (42 months [SEM = 0.7; CI: 40.5–43.5] vs. 54 months [SEM = 1.2; CI: 51.7–56.3]; p < 0.0001) in East Germany, whereas in West Germany no significant difference was observed (59 months [SEM = 0.8; CI: 57.4–60.6] vs. 60 months [SEM = 0.5; CI: 59.0–61.0]; p = 0.15). Conclusions Place of residence contributes to survival outcome of HNCP. Access to specialized care and socioeconomic factors could be improved in East Germany.

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