Nature Communications (Mar 2018)
Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells
- Chiara Cencioni,
- Francesco Spallotta,
- Matteo Savoia,
- Carsten Kuenne,
- Stefan Guenther,
- Agnese Re,
- Susanne Wingert,
- Maike Rehage,
- Duran Sürün,
- Mauro Siragusa,
- Jacob G. Smith,
- Frank Schnütgen,
- Harald von Melchner,
- Michael A. Rieger,
- Fabio Martelli,
- Antonella Riccio,
- Ingrid Fleming,
- Thomas Braun,
- Andreas M. Zeiher,
- Antonella Farsetti,
- Carlo Gaetano
Affiliations
- Chiara Cencioni
- Division of Cardiovascular Epigenetics, Department of Cardiology, Goethe University
- Francesco Spallotta
- Division of Cardiovascular Epigenetics, Department of Cardiology, Goethe University
- Matteo Savoia
- Division of Cardiovascular Epigenetics, Department of Cardiology, Goethe University
- Carsten Kuenne
- ECCPS Bioinformatics and deep sequencing platform, Max Planck Institute for Heart and Lung Research
- Stefan Guenther
- ECCPS Bioinformatics and deep sequencing platform, Max Planck Institute for Heart and Lung Research
- Agnese Re
- National Research Council, Institute of Cell Biology and Neurobiology (IBCN)
- Susanne Wingert
- LOEWE Center for Cell and Gene Therapy and Department of Medicine, Hematology/Oncology, Goethe University
- Maike Rehage
- LOEWE Center for Cell and Gene Therapy and Department of Medicine, Hematology/Oncology, Goethe University
- Duran Sürün
- LOEWE Center for Cell and Gene Therapy and Department of Medicine, Hematology/Oncology, Goethe University
- Mauro Siragusa
- Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
- Jacob G. Smith
- MRC Laboratory for Molecular Cell Biology, University College London
- Frank Schnütgen
- LOEWE Center for Cell and Gene Therapy and Department of Medicine, Hematology/Oncology, Goethe University
- Harald von Melchner
- LOEWE Center for Cell and Gene Therapy and Department of Medicine, Hematology/Oncology, Goethe University
- Michael A. Rieger
- LOEWE Center for Cell and Gene Therapy and Department of Medicine, Hematology/Oncology, Goethe University
- Fabio Martelli
- Molecular Cardiology Laboratory, IRCCS-Policlinico San Donato
- Antonella Riccio
- MRC Laboratory for Molecular Cell Biology, University College London
- Ingrid Fleming
- Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
- Thomas Braun
- Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
- Andreas M. Zeiher
- Internal Medicine Clinic III, Department of Cardiology, Goethe University
- Antonella Farsetti
- National Research Council, Institute of Cell Biology and Neurobiology (IBCN)
- Carlo Gaetano
- Division of Cardiovascular Epigenetics, Department of Cardiology, Goethe University
- DOI
- https://doi.org/10.1038/s41467-018-03668-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
The production of nitric oxide (NO) is required for early stage embryo implantation into the uterus. Here the authors show that during differentiation of naive mouse ESCs, early production of endogenous NO leads to a mesendoderm differentiation commitment pathway by inhibiting the action of the transcriptional repressor Zeb1.
