Nature Communications (Nov 2016)

Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion

  • Mandeep S. Singh,
  • Jasmin Balmer,
  • Alun R. Barnard,
  • Sher A. Aslam,
  • Daniela Moralli,
  • Catherine M. Green,
  • Alona Barnea-Cramer,
  • Isabel Duncan,
  • Robert E. MacLaren

DOI
https://doi.org/10.1038/ncomms13537
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 5

Abstract

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Previous studies have used fluorescently labelled cells to demonstrate the incorporation of transplanted photoreceptor precursors into the mouse retina. Here, the authors show that fluorescent proteins are passed between the host and transplanted cells rather than migration of donor cells into the retina.