The spectrally flat supercontinuum generation in the wavelength range of 900–2400 nm is demonstrated in silica-based fibers of variable core diameter and dispersion. It is shown that, in comparison with standard optical fibers of the same length, supercontinuum spectra 200 nm wider can be realized in the samples under study. The significant difference between the spectral and temporal transformations of radiation depending on the direction of propagation is demonstrated in the researched fiber samples.