Frontiers in Immunology (May 2022)
Salvage Endoscopic Skull Base Surgery: Another Treatment Option After Immunotherapy for Recurrent Nasopharyngeal Carcinoma
- Zhouying Peng,
- Zhouying Peng,
- Zhouying Peng,
- Zhouying Peng,
- Yumin Wang,
- Yumin Wang,
- Yumin Wang,
- Yumin Wang,
- Yan Fang,
- Yan Fang,
- Yan Fang,
- Yaxuan Wang,
- Yaxuan Wang,
- Yaxuan Wang,
- Xiaotian Yuan,
- Xiaotian Yuan,
- Mingxia Shuai,
- Mingxia Shuai,
- Mingxia Shuai,
- Mingxia Shuai,
- Shumin Xie,
- Shumin Xie,
- Shumin Xie,
- Shumin Xie,
- Ruohao Fan,
- Ruohao Fan,
- Ruohao Fan,
- Ruohao Fan,
- Hua Zhang,
- Hua Zhang,
- Hua Zhang,
- Hua Zhang,
- Zhihai Xie,
- Zhihai Xie,
- Zhihai Xie,
- Zhihai Xie,
- Weihong Jiang,
- Weihong Jiang,
- Weihong Jiang,
- Weihong Jiang
Affiliations
- Zhouying Peng
- Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China
- Zhouying Peng
- Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, China
- Zhouying Peng
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Zhouying Peng
- Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, China
- Yumin Wang
- Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China
- Yumin Wang
- Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, China
- Yumin Wang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Yumin Wang
- Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, China
- Yan Fang
- Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China
- Yan Fang
- Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, China
- Yan Fang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Yaxuan Wang
- Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China
- Yaxuan Wang
- Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, China
- Yaxuan Wang
- Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, China
- Xiaotian Yuan
- Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China
- Xiaotian Yuan
- Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, China
- Mingxia Shuai
- Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China
- Mingxia Shuai
- Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, China
- Mingxia Shuai
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Mingxia Shuai
- Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, China
- Shumin Xie
- Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China
- Shumin Xie
- Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, China
- Shumin Xie
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Shumin Xie
- Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, China
- Ruohao Fan
- Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China
- Ruohao Fan
- Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, China
- Ruohao Fan
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Ruohao Fan
- Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, China
- Hua Zhang
- Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China
- Hua Zhang
- Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, China
- Hua Zhang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Hua Zhang
- Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, China
- Zhihai Xie
- Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China
- Zhihai Xie
- Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, China
- Zhihai Xie
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Zhihai Xie
- Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, China
- Weihong Jiang
- Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China
- Weihong Jiang
- Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, China
- Weihong Jiang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Weihong Jiang
- Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fimmu.2022.899932
- Journal volume & issue
-
Vol. 13
Abstract
BackgroundAdvanced recurrent nasopharyngeal carcinoma (NPC) is a relatively common nasopharyngeal skull base disease for which there is no uniform treatment modality. Not all patients are satisfied with the efficacy of immunotherapy with or without chemotherapy.MethodsThis study included patients who underwent salvage endoscopic skull base nasopharyngectomy after immunotherapy between February 2017 and June 2021. Patient survival information was analyzed. Relevant publications were retrieved from five databases from December 1, 2011 to December 1, 2021. The outcomes of patients with advanced recurrent NPC who received programmed death 1 (PD-1) immunotherapy were collected and analyzed.ResultsNine patients who underwent skull base surgery, all of whom had previously undergone PD-1 immunotherapy, were included in this study. The 2-year overall survival (OS) and progression-free survival (PFS) rates of these patients were 25% and 29.2%, respectively. Eight publications involving 688 patients with advanced recurrent NPC were also included in this study. The combined complete response (CR), partial response (PR), and stable disease (SD) values were 2%, 23%, and 29%, respectively. The combined DCR included the three disease conditions, CR, PR, and SD, with a value of 53%. PD-1 monotherapy was more effective than PD-1 combination chemotherapy.ConclusionsPD-1 immunotherapy may improve the remission rate in patients with recurrent NPC. Salvage endoscopic skull base nasopharyngectomy may be another option for patients with poor immunotherapeutic outcomes. For patients with advanced recurrent NPC, better evidence-based medical data are needed to determine whether they should receive immunotherapy before or after surgery.
Keywords
- advanced recurrent nasopharyngeal carcinoma
- immunotherapy
- PD-1
- salvage endoscopic skull base nasopharyngectomy
- combination
