Nature Communications (Apr 2021)
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
- Alexander Beatty,
- Tanu Singh,
- Yulia Y. Tyurina,
- Vladimir A. Tyurin,
- Svetlana Samovich,
- Emmanuelle Nicolas,
- Kristen Maslar,
- Yan Zhou,
- Kathy Q. Cai,
- Yinfei Tan,
- Sebastian Doll,
- Marcus Conrad,
- Aravind Subramanian,
- Hülya Bayır,
- Valerian E. Kagan,
- Ulrike Rennefahrt,
- Jeffrey R. Peterson
Affiliations
- Alexander Beatty
- Fox Chase Cancer Center
- Tanu Singh
- Fox Chase Cancer Center
- Yulia Y. Tyurina
- Department of Environmental and Occupational Health, University of Pittsburgh
- Vladimir A. Tyurin
- Department of Environmental and Occupational Health, University of Pittsburgh
- Svetlana Samovich
- Department of Environmental and Occupational Health, University of Pittsburgh
- Emmanuelle Nicolas
- Fox Chase Cancer Center
- Kristen Maslar
- Department of Biochemistry and Molecular Biology, Drexel University College of Medicine
- Yan Zhou
- Fox Chase Cancer Center
- Kathy Q. Cai
- Fox Chase Cancer Center
- Yinfei Tan
- Fox Chase Cancer Center
- Sebastian Doll
- Institute of Metabolism and Cell Death, Helmholtz Zentrum München
- Marcus Conrad
- Institute of Metabolism and Cell Death, Helmholtz Zentrum München
- Aravind Subramanian
- Broad Institute of Harvard and MIT
- Hülya Bayır
- Department of Environmental and Occupational Health, University of Pittsburgh
- Valerian E. Kagan
- Department of Environmental and Occupational Health, University of Pittsburgh
- Ulrike Rennefahrt
- Metanomics Health GmbH
- Jeffrey R. Peterson
- Fox Chase Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-22471-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Inhibition of the lipid peroxidase GPX4 promotes ferroptotic cell death. Here, the authors identify a complementary approach using conjugated linolenic fatty acids that trigger lipid peroxidation and ferroptosis via ACSL1, DGAT1/2, and neutral lipids.
