Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1

Hang Cheng; Rajaa Sebaa; Nikita Malholtra; Baptiste Lacoste; Ziyad El Hankouri; Alexia Kirby; Nigel C. Bennett; Barry van Jaarsveld; Daniel W. Hart; Glenn J. Tattersall; Mary-Ellen Harper; Matthew E. Pamenter

doi:10.1038/s41467-021-27170-2

Nature Communications (Nov 2021)

Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1

Hang Cheng,
Rajaa Sebaa,
Nikita Malholtra,
Baptiste Lacoste,
Ziyad El Hankouri,
Alexia Kirby,
Nigel C. Bennett,
Barry van Jaarsveld,
Daniel W. Hart,
Glenn J. Tattersall,
Mary-Ellen Harper,
Matthew E. Pamenter

Affiliations

Hang Cheng: Department of Biology, University of Ottawa
Rajaa Sebaa: Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa
Nikita Malholtra: Department of Biology, University of Ottawa
Baptiste Lacoste: Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa
Ziyad El Hankouri: Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa
Alexia Kirby: Department of Biology, University of Ottawa
Nigel C. Bennett: Department of Zoology and Entomology, University of Pretoria
Barry van Jaarsveld: Department of Zoology and Entomology, University of Pretoria
Daniel W. Hart: Department of Zoology and Entomology, University of Pretoria
Glenn J. Tattersall: Department of Biological Sciences, Brock University
Mary-Ellen Harper: Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa
Matthew E. Pamenter: Department of Biology, University of Ottawa

DOI: https://doi.org/10.1038/s41467-021-27170-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Naked mole-rats are hypoxia-tolerant mammals, and during hypoxia their body temperature decreases via unknown mechanisms. Here the authors report that the hypoxia-induced body temperature decrease in naked mole rats occurs through decreased brown adipose tissue thermogenesis via decreases in a key thermogenic mitochondrial protein: UCP1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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