Veterinary Sciences (Nov 2023)

Extracutaneous Melanotic Melanoma with Nervous System Involvement in a Buffalo (<i>Bubalus bubalis</i>)

  • José Diomedes Barbosa,
  • Mariana Correia Oliveira,
  • Carlos Magno Chaves Oliveira,
  • Henrique dos Anjos Bomjardim,
  • Tatiane Teles Albernaz Ferreira,
  • Marcos Dutra Duarte,
  • José Alcides Sarmento da Silveira,
  • Natália da Silva e Silva Silveira,
  • Camila Cordeiro Barbosa,
  • Aluízio Otávio Almeida da Silva,
  • Anibal Armién,
  • Marilene de Farias Brito

DOI
https://doi.org/10.3390/vetsci10120662
Journal volume & issue
Vol. 10, no. 12
p. 662

Abstract

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Melanomas are tumors arising from externally uncontrolled melanocytes that produce varying amounts of melanin. In this study, we report a case of melanoma with neurological impairment without evidence of cutaneous neoplastic lesions in an adult buffalo in the state of Pará, Brazil. Clinically, the buffalo exhibited apathy, decreased mandibular tone, and occasionally an open mouth with motor incoordination, and eventually succumbed to the condition. Necropsy revealed multifocal tumor masses in the brain, pituitary gland, trigeminal ganglion, and spinal cord. The neoplastic cells showed strong positive signals for vimentin, Melan-A, PNL-2, and SOX10. The diagnosis was made via necropsy, histopathology, and positive immunostaining for Melan-A and PNL-2, which are specific markers for melanocyte identification.

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