Nature Communications (Nov 2018)
Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
- M. Welz,
- S. Eickhoff,
- Z. Abdullah,
- J. Trebicka,
- K. H. Gartlan,
- J. A. Spicer,
- A. J. Demetris,
- H. Akhlaghi,
- M. Anton,
- K. Manske,
- D. Zehn,
- B. Nieswandt,
- C. Kurts,
- J. A. Trapani,
- P. Knolle,
- D. Wohlleber,
- W. Kastenmüller
Affiliations
- M. Welz
- Institute of Experimental Immunology, University Hospital, University of Bonn
- S. Eickhoff
- Institute of Experimental Immunology, University Hospital, University of Bonn
- Z. Abdullah
- Institute of Experimental Immunology, University Hospital, University of Bonn
- J. Trebicka
- Department of Internal Medicine I, University of Bonn
- K. H. Gartlan
- QIMR Berghofer Medical Research Institute
- J. A. Spicer
- Auckland Cancer Society Research Centre, University of Auckland
- A. J. Demetris
- Department of Pathology, University of Pittsburgh
- H. Akhlaghi
- Peter MacCallum Cancer Centre
- M. Anton
- Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich
- K. Manske
- Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich
- D. Zehn
- Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich
- B. Nieswandt
- Institute of Experimental Biomedicine I, University of Wuerzburg
- C. Kurts
- Institute of Experimental Immunology, University Hospital, University of Bonn
- J. A. Trapani
- Peter MacCallum Cancer Centre
- P. Knolle
- Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich
- D. Wohlleber
- Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich
- W. Kastenmüller
- Institute of Experimental Immunology, University Hospital, University of Bonn
- DOI
- https://doi.org/10.1038/s41467-018-07213-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
CD8 T cells can protect the liver from viral infection, but can also result in severe liver damage and organ failure. Here, the authors develop a mouse model reflecting fulminant CD8 T cell mediated viral hepatitis, which occurs in a perforin-dependent manner that is protected by the use of perforin inhibitors.
