Nature Communications (May 2017)

Senescent tumor cells lead the collective invasion in thyroid cancer

  • Young Hwa Kim,
  • Yong Won Choi,
  • Jeonghun Lee,
  • Euy Young Soh,
  • Jang-Hee Kim,
  • Tae Jun Park

DOI
https://doi.org/10.1038/ncomms15208
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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The senescence-associated secretory phenotype of stromal cells can promote tumorigenesis. Here, the authors show that senescent cancer cells are localized at the invasive front in human papillary thyroid carcinoma, and that senescent cancer cells drive collective invasion via CXCL12 in mouse models.