Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells
Yannick Simonin,
Fabien Loustalot,
Caroline Desmetz,
Vincent Foulongne,
Orianne Constant,
Chantal Fournier-Wirth,
Fanny Leon,
Jean-Pierre Molès,
Aurélien Goubaud,
Jean-Marc Lemaitre,
Marianne Maquart,
Isabelle Leparc-Goffart,
Laurence Briant,
Nicolas Nagot,
Philippe Van de Perre,
Sara Salinas
Affiliations
Yannick Simonin
UMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, France
Fabien Loustalot
UMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, France
Caroline Desmetz
Université de Montpellier, Montpellier, France
Vincent Foulongne
UMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, France
Orianne Constant
UMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, France
Chantal Fournier-Wirth
UMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, France
Fanny Leon
UMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, France
Jean-Pierre Molès
UMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, France
Aurélien Goubaud
Institut de Médecine Régénératrice et Biothérapies, INSERM, U1183, Université de Montpellier, CHU Montpellier, Montpellier, France
Jean-Marc Lemaitre
Institut de Médecine Régénératrice et Biothérapies, INSERM, U1183, Université de Montpellier, CHU Montpellier, Montpellier, France
Marianne Maquart
Centre National de Référence des Arbovirus, Institut de Recherche Biomédicale des Armées, Marseille, France
Isabelle Leparc-Goffart
Centre National de Référence des Arbovirus, Institut de Recherche Biomédicale des Armées, Marseille, France
Laurence Briant
Centre d'études d'agents Pathogènes et Biotechnologies pour la Santé, FRE3689, CNRS-Université de Montpellier, Montpellier, France
Nicolas Nagot
UMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, France
Philippe Van de Perre
UMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, France
Sara Salinas
UMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, France
The recent Zika virus (ZIKV) epidemic has highlighted the poor knowledge on its physiopathology. Recent studies showed that ZIKV of the Asian lineage, responsible for this international outbreak, causes neuropathology in vitro and in vivo. However, two African lineages exist and the virus is currently found circulating in Africa. The original African strain was also suggested to be neurovirulent but its laboratory usage has been criticized due to its multiple passages. In this study, we compared the French Polynesian (Asian) ZIKV strain to an African strain isolated in Central African Republic and show a difference in infectivity and cellular response between both strains in human neural stem cells and astrocytes. Consistently, this African strain led to a higher infection rate and viral production, as well as stronger cell death and anti-viral response. Our results highlight the need to better characterize the physiopathology and predict neurological impairment associated with African ZIKV.
