Longitudinal Point Prevalence Survey of Antimicrobial Consumption in Russian Hospitals: Results of the Global-PPS Project
Svetlana Rachina,
Yuliya Belkova,
Roman Kozlov,
Ann Versporten,
Ines Pauwels,
Herman Goossens,
Elena Bochanova,
Olga Domanskaya,
Elena Elokhina,
Ludmila Ezhova,
Vladimir Mishchenko,
Oksana Ni,
Dmitry Popov,
Ulyana Portnjagina,
Evgeny Shchetinin,
Vera Shegimova,
Yulia Strezh,
Vera Vityazeva,
Nadezhda Zubareva,
Russian Global-PPS Project Study Group
Affiliations
Svetlana Rachina
Internal Medicine Department, First Moscow State Medical University, 119991 Moscow, Russia
Yuliya Belkova
Institute of Antimicrobial Chemotherapy, Smolensk State Medical University, 214019 Smolensk, Russia
Roman Kozlov
Institute of Antimicrobial Chemotherapy, Smolensk State Medical University, 214019 Smolensk, Russia
Ann Versporten
Vaccine & Infectious Disease Institute, University of Antwerp, 2610 Antwerp, Belgium
Ines Pauwels
Vaccine & Infectious Disease Institute, University of Antwerp, 2610 Antwerp, Belgium
Herman Goossens
Vaccine & Infectious Disease Institute, University of Antwerp, 2610 Antwerp, Belgium
Elena Bochanova
Department of Pharmacology and Pharmaceutical Consulting, Krasnoyarsk State Medical University n.a. Professor V. F. Voyno-Yasenetsky, 660022 Krasnoyarsk, Russia
Olga Domanskaya
Kuzbas Children’s Clinical Hospital n.a. Professor Y. Е. Malachovskiy, 654063 Novokuznetsk, Russia
Elena Elokhina
Omsk Regional Clinical Hospital, 644111 Omsk, Russia
Ludmila Ezhova
City Clinical Hospital n.a. V. V. Vinogradov, 117292 Moscow, Russia
Vladimir Mishchenko
Federal Centre of Traumatology, Orthopedics and Endoprosthesis Replacement, 214019 Smolensk, Russia
Oksana Ni
Regional Clinical Hospital no.2, 350012 Krasnodar, Russia
Dmitry Popov
National Medical Research Center for Cardiovascular Surgery n.a. A.N. Bakulev, 121552 Moscow, Russia
Ulyana Portnjagina
Department of Internal Medicine and General Medical Practice (Family Medicine), North-Eastern Federal University, 677007 Yakutsk, Russia
Evgeny Shchetinin
Department of Pathological Physiology, Stavropol State Medical University, 355017 Stavropol, Russia
Vera Shegimova
Republican Clinical Hospital n.a. N.A. Semashko, 670031 Ulan-Ude, Russia
Yulia Strezh
Tomsk Regional Clinical Hospital, 634063 Tomsk, Russia
Vera Vityazeva
Republican Children’s Hospital, 185000 Petrozavodsk, Russia
Nadezhda Zubareva
General Surgery Department #1, Perm State Medical University n.a. E.A. Vagner, 614000 Perm, Russia
Antimicrobial resistance is one of the key issues limiting the successful treatment of infectious diseases and associated with adverse medical, social and economic consequences on a global scale. The present study aims to evaluate antimicrobials prescribing patterns and assess progress in quality indicators in Russian multidisciplinary hospitals using three repetitive point prevalence studies (PPSs) over 4 years (Global-PPS 2015, 2017 and 2018). Out of 13,595 patients from 21 hospitals surveyed over the three time points, 3542 (26.14%) received antimicrobials, predominantly third-generation cephalosporins (44.7% in 2015, 34.1% in 2017 and 41.8% in 2018). Compliance with the hospital antibiotic guidelines was 74.8%, 66.8% and 74.3%, respectively. Indication for treatment was recorded in 72.6%, 84.1% and 82.6%, while stop/review date was documented only in 40.5%, 46.5% and 61.1% of cases. Perioperative antibiotic prophylaxis exceeded 1 day in 92%, 84% and 81% of cases. Targeted therapy rate at all time points did not exceed 15.1%, treatment based on the biomarkers rate—19.9%. For the part of PPS-2017 and 2018 analyzed in dynamics, no prominent trends were noted. The results of the project provide the basis for the development of appropriate antimicrobial stewardship programs tailored according to local practices for each hospital in the project.
