Nature Communications (Jan 2018)
A dual role for the N-terminal domain of the IL-3 receptor in cell signalling
- Sophie E. Broughton,
- Timothy R. Hercus,
- Tracy L. Nero,
- Winnie L. Kan,
- Emma F. Barry,
- Mara Dottore,
- Karen S. Cheung Tung Shing,
- Craig J. Morton,
- Urmi Dhagat,
- Matthew P. Hardy,
- Nicholas J. Wilson,
- Matthew T. Downton,
- Christine Schieber,
- Timothy P. Hughes,
- Angel F. Lopez,
- Michael W. Parker
Affiliations
- Sophie E. Broughton
- Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research
- Timothy R. Hercus
- The Centre for Cancer Biology, SA Pathology and the University of South Australia
- Tracy L. Nero
- Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research
- Winnie L. Kan
- The Centre for Cancer Biology, SA Pathology and the University of South Australia
- Emma F. Barry
- The Centre for Cancer Biology, SA Pathology and the University of South Australia
- Mara Dottore
- The Centre for Cancer Biology, SA Pathology and the University of South Australia
- Karen S. Cheung Tung Shing
- Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research
- Craig J. Morton
- Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research
- Urmi Dhagat
- Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research
- Matthew P. Hardy
- CSL Limited
- Nicholas J. Wilson
- CSL Limited
- Matthew T. Downton
- IBM Research Australia
- Christine Schieber
- IBM Research Australia
- Timothy P. Hughes
- South Australian Health and Medical Research Institute and University of Adelaide
- Angel F. Lopez
- The Centre for Cancer Biology, SA Pathology and the University of South Australia
- Michael W. Parker
- Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research
- DOI
- https://doi.org/10.1038/s41467-017-02633-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
The N-terminal domain (NTD) of interleukin-3 receptor α-subunit (IL3Rα) is involved in IL-3 recognition but the underlying mechanism is unknown. Here, the authors present crystal structures of the IL3Rα complex and provide biochemical evidence that the NTD regulates IL-3 binding and signalling complex assembly.
