Clinical Case Reports (Nov 2021)
Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
Abstract
Abstract Lamotrigine has been repeatedly reported to cause hematologic toxicities, which may be associated with high initial doses or excessive escalation. A 29‐year‐old lady experienced profound neutropenia after two weeks of lamotrigine high initial dose, started within two days of phenytoin. The too‐early dose intensification may have produced lamotrigine‐induced blood dyscrasia.
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