Clinical Case Reports (Nov 2021)

Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin

  • Muhammad Salem,
  • Ahmed El‐Bardissy

DOI
https://doi.org/10.1002/ccr3.5136
Journal volume & issue
Vol. 9, no. 11
pp. n/a – n/a

Abstract

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Abstract Lamotrigine has been repeatedly reported to cause hematologic toxicities, which may be associated with high initial doses or excessive escalation. A 29‐year‐old lady experienced profound neutropenia after two weeks of lamotrigine high initial dose, started within two days of phenytoin. The too‐early dose intensification may have produced lamotrigine‐induced blood dyscrasia.

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