The Relative Cerebral Blood Volume (rCBV) < 42% Is Independently Associated with Collateral Status in Anterior Circulation Large Vessel Occlusion

Dhairya A. Lakhani; Aneri B. Balar; Manisha Koneru; Sijin Wen; Burak Berksu Ozkara; Hanzhang Lu; Richard Wang; Meisam Hoseinyazdi; Janet Mei; Risheng Xu; Mehreen Nabi; Ishan Mazumdar; Andrew Cho; Kevin Chen; Sadra Sepehri; Nathan Hyson; Victor Urrutia; Licia Luna; Argye E. Hillis; Jeremy J. Heit; Greg W. Albers; Ansaar T. Rai; Adam A. Dmytriw; Tobias Faizy; Max Wintermark; Kambiz Nael; Vivek S. Yedavalli

doi:10.3390/jcm13061588

Journal of Clinical Medicine (Mar 2024)

The Relative Cerebral Blood Volume (rCBV) < 42% Is Independently Associated with Collateral Status in Anterior Circulation Large Vessel Occlusion

Dhairya A. Lakhani,
Aneri B. Balar,
Manisha Koneru,
Sijin Wen,
Burak Berksu Ozkara,
Hanzhang Lu,
Richard Wang,
Meisam Hoseinyazdi,
Janet Mei,
Risheng Xu,
Mehreen Nabi,
Ishan Mazumdar,
Andrew Cho,
Kevin Chen,
Sadra Sepehri,
Nathan Hyson,
Victor Urrutia,
Licia Luna,
Argye E. Hillis,
Jeremy J. Heit,
Greg W. Albers,
Ansaar T. Rai,
Adam A. Dmytriw,
Tobias Faizy,
Max Wintermark,
Kambiz Nael,
Vivek S. Yedavalli

Affiliations

Dhairya A. Lakhani: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Aneri B. Balar: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Manisha Koneru: Cooper Medical School, Rowan University, Camden, NJ 08103, USA
Sijin Wen: Department of Biostatistics, West Virginia University, Morgantown, WV 26506, USA
Burak Berksu Ozkara: Department of Neurology, Johns Hopkins University, Baltimore, MD 21218, USA
Hanzhang Lu: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Richard Wang: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Meisam Hoseinyazdi: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Janet Mei: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Risheng Xu: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Mehreen Nabi: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Ishan Mazumdar: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Andrew Cho: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Kevin Chen: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Sadra Sepehri: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Nathan Hyson: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Victor Urrutia: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Licia Luna: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Argye E. Hillis: Department of Neurology, Johns Hopkins University, Baltimore, MD 21218, USA
Jeremy J. Heit: Department of Neurology, Stanford University, Stanford, CA 94305, USA
Greg W. Albers: Department of Neurology, Stanford University, Stanford, CA 94305, USA
Ansaar T. Rai: Department of Neuroradiology, West Virginia University, Morgantown, WV 26506, USA
Adam A. Dmytriw: Department of Radiology, Harvarvd Medical School, Boston, MA 02115, USA
Tobias Faizy: Department of Radiology, Neuroendovascular Division, University Medical Center Münster, 48149 Münster, Germany
Max Wintermark: Department of Neuroradiology, MD Anderson Medical Center, Houston, TX 77030, USA
Kambiz Nael: Division of Neuroradiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Vivek S. Yedavalli: Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA

DOI: https://doi.org/10.3390/jcm13061588
Journal volume & issue: Vol. 13, no. 6
p. 1588

Abstract

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Background: The pretreatment CT perfusion (CTP) marker the relative cerebral blood volume (rCBV) Methods: In this retrospective evaluation of our prospectively collected database, we included acute stroke patients triaged by multimodal CT imaging, including CT angiography and perfusion imaging, with confirmed anterior circulation large vessel occlusion between 1 September 2017 and 1 October 2023. Group differences were assessed using the Student’s t test, Mann–Whitney U test and Chi-Square test. Spearman’s rank correlation and logistic regression analyses were used to assess associations between rCBV Results: In total, 222 patients (median age: 69 years, 56.3% female) met our inclusion criteria. In the multivariable logistic regression analysis, taking into account age, sex, race, hypertension, hyperlipidemia, diabetes, atrial fibrillation, prior stroke or transient ischemic attack, the admission National Institute of Health stroke scale, the premorbid modified Rankin score, the Alberta stroke program early CT score (ASPECTS), and segment occlusion, the rCBV p Conclusion: The rCBV < 42% lesion volume is independently associated with the DSA CS.

Published in Journal of Clinical Medicine

ISSN: 2077-0383 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/jcm

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