Nature Communications (Jul 2018)
Abnormal RNA stability in amyotrophic lateral sclerosis
- E. M. Tank,
- C. Figueroa-Romero,
- L. M. Hinder,
- K. Bedi,
- H. C. Archbold,
- X. Li,
- K. Weskamp,
- N. Safren,
- X. Paez-Colasante,
- C. Pacut,
- S. Thumma,
- M. T. Paulsen,
- K. Guo,
- J. Hur,
- M. Ljungman,
- E. L. Feldman,
- S. J. Barmada
Affiliations
- E. M. Tank
- Department of Neurology, University of Michigan Medical School
- C. Figueroa-Romero
- Department of Neurology, University of Michigan Medical School
- L. M. Hinder
- Department of Neurology, University of Michigan Medical School
- K. Bedi
- Department of Radiation Oncology, University of Michigan Medical School
- H. C. Archbold
- Department of Neurology, University of Michigan Medical School
- X. Li
- Department of Neurology, University of Michigan Medical School
- K. Weskamp
- Department of Neurology, University of Michigan Medical School
- N. Safren
- Department of Neurology, University of Michigan Medical School
- X. Paez-Colasante
- Department of Neurology, University of Michigan Medical School
- C. Pacut
- Department of Neurology, University of Michigan Medical School
- S. Thumma
- Department of Neurology, University of Michigan Medical School
- M. T. Paulsen
- Department of Radiation Oncology, University of Michigan Medical School
- K. Guo
- Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota
- J. Hur
- Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota
- M. Ljungman
- Department of Radiation Oncology, University of Michigan Medical School
- E. L. Feldman
- Department of Neurology, University of Michigan Medical School
- S. J. Barmada
- Department of Neurology, University of Michigan Medical School
- DOI
- https://doi.org/10.1038/s41467-018-05049-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
RNA instability may be a contributing factor in amyotrophic lateral sclerosis (ALS). Here the authors carry out genome-wide assessment of RNA synthesis and stability in cells derived from patients with C9orf72 ALS, sporadic ALS and healthy controls.
