mBio
(Apr 2021)
Strain-Resolved Dynamics of the Lung Microbiome in Patients with Cystic Fibrosis
Marija Dmitrijeva,
Christian R. Kahlert,
Rounak Feigelman,
Rebekka L. Kleiner,
Oliver Nolte,
Werner C. Albrich,
Florent Baty,
Christian von Mering
Affiliations
Marija Dmitrijeva
Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland
Christian R. Kahlert
Infectious Diseases and Hospital Epidemiology, Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland
Rounak Feigelman
Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland
Rebekka L. Kleiner
Pneumology and Sleep Medicine, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
Oliver Nolte
Human Microbiology, Centre for Laboratory Medicine, St. Gallen, Switzerland
Werner C. Albrich
Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
Florent Baty
Pneumology and Sleep Medicine, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
Christian von Mering
ORCiD Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland
DOI
https://doi.org/10.1128/mBio.02863-20
Journal volume & issue
Vol. 12,
no. 2
Abstract
Read online
Cystic fibrosis patients frequently suffer from recurring respiratory infections caused by colonizing pathogenic and commensal bacteria. Although modern therapies can sometimes alleviate respiratory symptoms by ameliorating residual function of the protein responsible for the disorder, management of chronic respiratory infections remains an issue.
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