Nature Communications (Apr 2019)
Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch
- Hirotaka Tao,
- Min Zhu,
- Kimberly Lau,
- Owen K. W. Whitley,
- Mohammad Samani,
- Xiao Xiao,
- Xiao Xiao Chen,
- Noah A. Hahn,
- Weifan Liu,
- Megan Valencia,
- Min Wu,
- Xian Wang,
- Kelli D. Fenelon,
- Clarissa C. Pasiliao,
- Di Hu,
- Jinchun Wu,
- Shoshana Spring,
- James Ferguson,
- Edith P. Karuna,
- R. Mark Henkelman,
- Alexander Dunn,
- Huaxiong Huang,
- Hsin-Yi Henry Ho,
- Radhika Atit,
- Sidhartha Goyal,
- Yu Sun,
- Sevan Hopyan
Affiliations
- Hirotaka Tao
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Min Zhu
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Kimberly Lau
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Owen K. W. Whitley
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Mohammad Samani
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Xiao Xiao
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Xiao Xiao Chen
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Noah A. Hahn
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Weifan Liu
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Megan Valencia
- Department of Molecular Genetics, University of Toronto
- Min Wu
- Department of Molecular Genetics, University of Toronto
- Xian Wang
- Department of Mechanical and Industrial Engineering and Institute of Biomaterials and Biomedical Engineering, University of Toronto
- Kelli D. Fenelon
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Clarissa C. Pasiliao
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Di Hu
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Jinchun Wu
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- Shoshana Spring
- Mouse Imaging Centre, Hospital for Sick Children, Department of Medical Biophysics, University of Toronto
- James Ferguson
- Department of Biology, Case Western Reserve University
- Edith P. Karuna
- Department of Cell Biology and Human Anatomy, University of California, Davis School of Medicine
- R. Mark Henkelman
- Mouse Imaging Centre, Hospital for Sick Children, Department of Medical Biophysics, University of Toronto
- Alexander Dunn
- Department of Chemical Engineering, Stanford University
- Huaxiong Huang
- Department of Mathematics and Statistics, York University
- Hsin-Yi Henry Ho
- Department of Cell Biology and Human Anatomy, University of California, Davis School of Medicine
- Radhika Atit
- Department of Biology, Case Western Reserve University
- Sidhartha Goyal
- Department of Physics, University of Toronto
- Yu Sun
- Department of Mechanical and Industrial Engineering and Institute of Biomaterials and Biomedical Engineering, University of Toronto
- Sevan Hopyan
- Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children
- DOI
- https://doi.org/10.1038/s41467-019-09540-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Morphogenesis of tissue sheets is well studied, but mechanisms that shape bulk tissues are unclear. Here, the authors show that mesenchymal cells intercalate in 3D to shape the mouse branchial arch, with cortical forces driving intercalations in a Wnt5a-, Yap/Taz- and Piezo1-dependent manner.
