Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel

Mykhaylo Slobodyanyuk; Jesús A. Banda-Vázquez; Mackenzie J. Thompson; Rebecca A. Dean; John E. Baenziger; Roberto A. Chica; Corrie J. B. daCosta

doi:10.1038/s42003-022-04227-6

Communications Biology (Nov 2022)

Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel

Mykhaylo Slobodyanyuk,
Jesús A. Banda-Vázquez,
Mackenzie J. Thompson,
Rebecca A. Dean,
John E. Baenziger,
Roberto A. Chica,
Corrie J. B. daCosta

Affiliations

Mykhaylo Slobodyanyuk: Department of Chemistry and Biomolecular Sciences, University of Ottawa
Jesús A. Banda-Vázquez: Department of Chemistry and Biomolecular Sciences, University of Ottawa
Mackenzie J. Thompson: Department of Biochemistry, Microbiology, and Immunology, University of Ottawa
Rebecca A. Dean: Department of Chemistry and Biomolecular Sciences, University of Ottawa
John E. Baenziger: Department of Biochemistry, Microbiology, and Immunology, University of Ottawa
Roberto A. Chica: Department of Chemistry and Biomolecular Sciences, University of Ottawa
Corrie J. B. daCosta: Department of Chemistry and Biomolecular Sciences, University of Ottawa

DOI: https://doi.org/10.1038/s42003-022-04227-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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A structural and functional study of the prokaryotic ligand-gated ion channel, ELIC, provides insight into the origin of agonism and antagonism at nicotinic acetylcholine receptors.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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