Additional diagnostic immunocytochemical criteria for T/NK-cell lymphomas

Abstract

896 patients (pts) with malignant non-Hodgkin's lymphomas were examined in this study. Т-cell immunophenotype has been established in 208 cases. Diagnosis was established according to the WHO criteria. We used the panel from 15 monoclonal antibodies for the detailed characteristic of Т-cell immunophenotype of non-Hodgkin's lymphomas. Lymphoblastic lymphomas was revealed in 115 pts and peripheral T-lymphomas in 93 pts. It was shown, that immunocytochemical research with quantitative calculation of antigen-positive cells has the certain value for differential diagnostics of peripheral Tcell lymphomas. We determined some quantitative diagnostics criteria in addition to WHO classification and proved their evidence in malignancy heterogeneity typical for T-cell lymphomas.

Keywords

• non-hodgkin's t-cell lymphomas
• classification of t-cell neoplasms
• additional quantitative immunocytochemical criteria