Rate of Weight Gain and its Association with Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) among Obese Children attending Paediatric Endocrine Clinic, Hospital Universiti Sains Malaysia

Abstract

Objective. We aimed to study the median time to gain weight from baseline and factors that were associated with rate of weight gain among obese children attending pediatric endocrine clinic Hospital USM. Methodology. We recruited 70 participants with the mean age of 10.1 + 2.94 years with exogenous or simple form of obesity from June 2019 until September 2020. We analyzed their demography (age, gender, ethnicity, family background), measured their anthropometry (weight, height, BMI) and monitored monthly weight increment and finally analyzed their HOMA-IR at baseline and after 6 months of follow up. Results. The mean time to gain 5 kg from baseline was 16 weeks (95% CI): (15.2, 16.7). Multivariate analysis showed only HOMA-IR after 6 months was a significant predictor affecting time to gain 5 kg; Adjusted HR: (95%CI) 1.617(1.232, 2.123), (p=0.001). Conclusion. The time to gain 5 kg from baseline weight was increased 1.6 times in the presence of insulin resistance at 6 months follow up in patients with obesity. More intensive education and closed follow-up are recommended for children with obesity.

Keywords

• HOMA-IR
• prognostic factor
• obesity
• insulin resistance