Nature Communications (Jul 2021)
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
- Virginia Giuliani,
- Meredith A. Miller,
- Chiu-Yi Liu,
- Stella R. Hartono,
- Caleb A. Class,
- Christopher A. Bristow,
- Erika Suzuki,
- Lionel A. Sanz,
- Guang Gao,
- Jason P. Gay,
- Ningping Feng,
- Johnathon L. Rose,
- Hideo Tomihara,
- Joseph R. Daniele,
- Michael D. Peoples,
- Jennifer P. Bardenhagen,
- Mary K. Geck Do,
- Qing E. Chang,
- Bhavatarini Vangamudi,
- Christopher Vellano,
- Haoqiang Ying,
- Angela K. Deem,
- Kim-Anh Do,
- Giannicola Genovese,
- Joseph R. Marszalek,
- Jeffrey J. Kovacs,
- Michael Kim,
- Jason B. Fleming,
- Ernesto Guccione,
- Andrea Viale,
- Anirban Maitra,
- M. Emilia Di Francesco,
- Timothy A. Yap,
- Philip Jones,
- Giulio Draetta,
- Alessandro Carugo,
- Frederic Chedin,
- Timothy P. Heffernan
Affiliations
- Virginia Giuliani
- Traction, The University of Texas MD Anderson Cancer Center
- Meredith A. Miller
- Traction, The University of Texas MD Anderson Cancer Center
- Chiu-Yi Liu
- Traction, The University of Texas MD Anderson Cancer Center
- Stella R. Hartono
- Department of Molecular and Cellular Biology and Genome Center, University of California
- Caleb A. Class
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Christopher A. Bristow
- Traction, The University of Texas MD Anderson Cancer Center
- Erika Suzuki
- Traction, The University of Texas MD Anderson Cancer Center
- Lionel A. Sanz
- Department of Molecular and Cellular Biology and Genome Center, University of California
- Guang Gao
- Traction, The University of Texas MD Anderson Cancer Center
- Jason P. Gay
- Traction, The University of Texas MD Anderson Cancer Center
- Ningping Feng
- Traction, The University of Texas MD Anderson Cancer Center
- Johnathon L. Rose
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Hideo Tomihara
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Joseph R. Daniele
- Traction, The University of Texas MD Anderson Cancer Center
- Michael D. Peoples
- Traction, The University of Texas MD Anderson Cancer Center
- Jennifer P. Bardenhagen
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Mary K. Geck Do
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Qing E. Chang
- ORBIT, The University of Texas MD Anderson Cancer Center
- Bhavatarini Vangamudi
- Traction, The University of Texas MD Anderson Cancer Center
- Christopher Vellano
- Traction, The University of Texas MD Anderson Cancer Center
- Haoqiang Ying
- Department of Cellular and Molecular Oncology, The University of Texas MD Anderson Cancer Center
- Angela K. Deem
- Traction, The University of Texas MD Anderson Cancer Center
- Kim-Anh Do
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Giannicola Genovese
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Joseph R. Marszalek
- Traction, The University of Texas MD Anderson Cancer Center
- Jeffrey J. Kovacs
- Traction, The University of Texas MD Anderson Cancer Center
- Michael Kim
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Jason B. Fleming
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Ernesto Guccione
- Department of Oncological Sciences and Pharmacological Sciences at Icahn School of Medicine at Mount Sinai
- Andrea Viale
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Anirban Maitra
- Sheikh Ahmed Bin Zayed Al Nahyan Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center
- M. Emilia Di Francesco
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Timothy A. Yap
- Department of Investigational Cancer Therapeutics (Phase I Program), The University of Texas MD Anderson Cancer Center
- Philip Jones
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Giulio Draetta
- Traction, The University of Texas MD Anderson Cancer Center
- Alessandro Carugo
- Traction, The University of Texas MD Anderson Cancer Center
- Frederic Chedin
- Department of Molecular and Cellular Biology and Genome Center, University of California
- Timothy P. Heffernan
- Traction, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-24798-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Arginine methylation by PRMTs is dysregulated in cancer. Here, the authors use functional genomics screens and identify PRMT1 as a vulnerability in pancreatic ductal adenocarcinoma, and further show that PRMT1 regulates RNA metabolism and coordinates expression of genes in cell cycle progression, maintaining genomic stability and tumour growth.
