Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation

Abstract

Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation. The signaling pathways that differentiate between a permanent or transient activation state of platelets are poorly elucidated.

Keywords

• integrin αIIbβ3
• glycoprotein VI
• P-selectin
• protease-activated receptors
• protein kinase C