Clinical profile and outcome of critically sick patients of dengue, admitted in PICU of a tertiary care center

Abstract

Background: India is among the countries reporting regular outbreaks of Dengue infection. Present study describes clinical profile and outcome of severe dengue cases. Methods: It is a retrospective observational study. All dengue patients admitted in PICU, from June 2015 to December 2015 were classified as per new WHO-2009 classification, and only those with severe dengue were included in the study. Clinical features, laboratory parameters and final outcome were studied and described. Results: Fever, pain abdomen and vomiting were found to be most common presenting symptoms. Thrombocytopenia was found in 100% cases and leukopenia in 20% cases. Shock was present in all the patients and average time taken for shock reversal was 2.4 days. Hepatitis (68.5%), AKI (54%) and encephalitis (14.2%) were the main complications. Survival rate was 91.4%. Conclusion: renal and CNS involvement is more common in dengue then previously reported. Use of inotropes and mechanical ventilation are associated with higher mortality.

Keywords

• severe dengue
• shock
• thrombocytopenia
• pelod score