Nature Communications (Nov 2020)

A universal dual mechanism immunotherapy for the treatment of influenza virus infections

  • Xin Liu,
  • Boning Zhang,
  • Yingcai Wang,
  • Hanan S. Haymour,
  • Fenghua Zhang,
  • Le-cun Xu,
  • Madduri Srinivasarao,
  • Philip S. Low

DOI
https://doi.org/10.1038/s41467-020-19386-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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In this study, the authors combine an anti-viral drug and immune system inducer to treat influenza A and B viral infections in vitro and in vivo. They show that the compound outperforms zanamivir alone as it is still able to clear infection three days post infection, and it can be administered via different routes without reduced efficacy.