One Pot Synthesis of Alpha-Aminonitrile and Alpha-Amino Acid From Schiff Bases

Abstract

Addition of Potassium cyanide to a mixture of Schiff base and lithium perchlorate afforded a-aminonitriles in high yields. Addition of potassium cyanide to a methanolic solution of Schiff base and phosphoric acid afforded a-aminonitriles. When the reaction mixture was refluxed it gave a-amino acids in high yields.

Keywords

• alpha-aminonitriles
• alpha-amino acids
• schiff bases