Nature Communications (Feb 2023)

Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter

  • James S. Davies,
  • Michael J. Currie,
  • Rachel A. North,
  • Mariafrancesca Scalise,
  • Joshua D. Wright,
  • Jack M. Copping,
  • Daniela M. Remus,
  • Ashutosh Gulati,
  • Dustin R. Morado,
  • Sam A. Jamieson,
  • Michael C. Newton-Vesty,
  • Gayan S. Abeysekera,
  • Subramanian Ramaswamy,
  • Rosmarie Friemann,
  • Soichi Wakatsuki,
  • Jane R. Allison,
  • Cesare Indiveri,
  • David Drew,
  • Peter D. Mace,
  • Renwick C. J. Dobson

DOI
https://doi.org/10.1038/s41467-023-36590-1
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 12

Abstract

Read online

Bacteria and archaea use tripartite ATP-independent periplasmic (TRAP) transporters to import essential nutrients. Davies et al. report a high resolution structure of a TRAP and show that it uses an ‘elevator-with-an operator’ mechanism.