Nature Communications (Jan 2019)

Promoter-proximal pausing mediated by the exon junction complex regulates splicing

  • Junaid Akhtar,
  • Nastasja Kreim,
  • Federico Marini,
  • Giriram Mohana,
  • Daniel Brüne,
  • Harald Binder,
  • Jean-Yves Roignant

DOI
https://doi.org/10.1038/s41467-019-08381-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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The exon junction complex (EJC) has been identified as functioning as a post-transcriptional gene regulator. Here the authors reveal that the complex also plays a part in the regulation of transcription by regulating the release of Pol II pausing into transcription elongation.