Nature Communications (Aug 2018)
Programmed cell removal by calreticulin in tissue homeostasis and cancer
- Mingye Feng,
- Kristopher D. Marjon,
- Fangfang Zhu,
- Rachel Weissman-Tsukamoto,
- Aaron Levett,
- Katie Sullivan,
- Kevin S. Kao,
- Maxim Markovic,
- Paul A. Bump,
- Hannah M. Jackson,
- Timothy S. Choi,
- Jing Chen,
- Allison M. Banuelos,
- Jie Liu,
- Phung Gip,
- Lei Cheng,
- Denong Wang,
- Irving L. Weissman
Affiliations
- Mingye Feng
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Kristopher D. Marjon
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Fangfang Zhu
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Rachel Weissman-Tsukamoto
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Aaron Levett
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Katie Sullivan
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Kevin S. Kao
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Maxim Markovic
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Paul A. Bump
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Hannah M. Jackson
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Timothy S. Choi
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Jing Chen
- Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center
- Allison M. Banuelos
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Jie Liu
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Phung Gip
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Lei Cheng
- State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and West China Hospital of Stomatology, Sichuan University
- Denong Wang
- SRI International
- Irving L. Weissman
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- DOI
- https://doi.org/10.1038/s41467-018-05211-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Macrophage-mediated programmed cell removal (PrCR) allows clearance of living cells. Here the authors show that, in mouse models, activated macrophages create an “eat me” signal via calreticulin secretion on neutrophils during peritonitis and on cancer cells, determining in both cases clearance by PrCR.
